Article1993

Aspartic Acid Racemization in Intervertebral Discs as an Aid to Postmortem Estimation of Age at Death

51 citations0/0 files storedJournal of Forensic Sciences

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Forensic Anthropology and Bioarchaeology Studies Archaeology and ancient environmental studies Forensic Entomology and Diptera Studies

Abstract

We investigated whether measurement of aspartic acid racemization in intervertebral discs (IVD) could be used in the postmortem estimation of age at death. The extent of aspartic acid racemization in IVD tissues was found to increase with age. The rate of racemization turned out to be much higher in the nucleus pulposus than in the annulus fibrosus. The relation between age and the D-aspartic acid content in the anterior peripheral annulus fibrosus of IVD was close enough to allow postmortem estimation of age at death based on the extent of aspartic acid racemization in this tissue.

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References

1975Aspartic acid racemization in tooth enamel from living humans.1991Age Estimation Using the Racemization of Amino Acid in Human Dentin 1985Application of aspartic acid racemization to forensic odontology: Post mortem designation of age at death 1990The extent of aspartic acid racemization in dentin: a possible method for a more accurate determination of age at death?

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1994Estimation of age at death based on aspartic acid racemization in noncollagenous bone proteins 2009Aspartic acid racemisation in purified elastin from arteries as basis for age estimation 1995Estimation of chronologic age using the aspartic acid racemization method. I. On human rib cartilage 2019Age estimation based on different molecular clocks in several tissues and a multivariate approach: an explorative study 2010Ascertaining year of birth/age at death in forensic cases: A review of conventional methods and methods allowing for absolute chronology 1995Estimation of chronologic age using the aspartic acid racemization method. II. On human cortical bone 2014Age estimation of skeletal remains: principal methods 2013Forensic anthropology and human identification

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