Article1989

Nuclear magnetic resonance study of obsessive-compulsive disorder

Howard J. Garber · J. Ananth · Lee C. Chiu · Virginia J. Griswold · William H. Oldendorf

128 citations0/0 files storedAmerican Journal of Psychiatry

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Obsessive-Compulsive Spectrum Disorders Psychoanalysis and Psychopathology Research Neural and Behavioral Psychology Studies

Abstract

Magnetic resonance imaging (MRI) of the brains of 32 patients who met the DSM-III criteria for obsessive-compulsive disorder and of 14 normal subjects frequently revealed abnormalities, but none was specific to obsessive-compulsive disorder. Spin-lattice relaxation time (T1) for right frontal white matter was prolonged in the patients compared to the control subjects, and the patients had greater right-minus-left T1 differences for frontal white matter. Right-minus-left T1 differences in the orbital frontal cortex were strongly correlated with symptom severity in the unmedicated patients and in the patients with family histories of obsessive-compulsive disorder.

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References

1987Local Cerebral Glucose Metabolic Rates in Obsessive-Compulsive Disorder 1990Local Cerebral Glucose Metabolic Rates in Obsessive-Compulsive Disorder 1988Neuroanatomical abnormalities in obsessive-compulsive disorder detected with quantitative X-ray computed tomography 1984Computerized tomography and neuropsychological test measures in adolescents with obsessive-compulsive disorder 1983Neurological and neuropsychological studies of patients with obsessive-compulsive disorder.

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1991Brain MRI in obsessive-compulsive disorder 1997NEUROBIOLOGY OF TOURETTE SYNDROME 1992Neurobiology of Obsessive Compulsive Disorder 2019Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium 2001Tc-99m HMPAO brain perfusion SPECT in drug-free obsessive-compulsive patients without depression 1992Normal and Abnormal Information Processing: A Neuropsychological Perspective on Obsessive Compulsive Disorder 2006Increased Medial Thalamic Creatine-Phosphocreatine Found by Proton Magnetic Resonance Spectroscopy in Children With Obsessive-Compulsive Disorder Versus Major Depression and Healthy Controls

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