Article1996

Patterns of personality disorder comorbidity in early-onset versus late- onset major depression

Maurizio Fava M. D · Jonathan E. Alpert · Joseph S. Borus · Andrew Alan Nierenberg · Joel A. Pava · Jerrold F. Rosenbaum

118 citations0/0 files storedAmerican Journal of Psychiatry

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Personality Disorders and Psychopathology Personality Traits and Psychology Bipolar Disorder and Treatment

Abstract

OBJECTIVE: This study tested the hypothesis that in a population of adult outpatients with major depression, those with an early onset of depression would have a greater prevalence of personality disorders than those with a late onset of depression. METHOD: The 404 subjects were patients participating in depression treatment studies at the Massachusetts General Hospital. They were administered the Structured Clinical Interview for DSM-III-R-Patient Version to assess the current presence of major depression and the age at onset of the initial depressive episode. The subjects were then divided into two groups: those with early onset (before 18 years of age) and those with late onset (at age 18 or later). The prevalence of personality disorders was determined through use of the physician-rated Structured Clinical Interview for DSM-III-R Personality Disorders (SCID-II) and the patient-rated Personality Diagnostic Questionnaire-Revised (PDQ-R). RESULTS: The patients with early onset of major depression had a significantly higher prevalence of avoidant, histrionic, narcissistic, and borderline personality disorders according to the SCID-II. The PDQ-R scores indicated that avoidant, dependent, passive-aggressive, histrionic, narcissistic, borderline, and antisocial personality disorders were significantly more prevalent among the patients with early onset of major depression. CONCLUSIONS: Overall, the results are consistent with the view that early-onset depressive illness is distinguished from late-onset major depression by more frequent association with persistent disturbances in behaviors and attitudes.

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References

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2004Familial Transmission of Mood Disorders: Convergence and Divergence With Transmission of Suicidal Behavior 2009Childhood Onset Major Depressive Disorder: Course of Illness and Psychiatric Comorbidity in a Community Sample 1999Relationship between depression and borderline personality disorder 2006Chronic depression: Interpersonal sources, therapeutic solutions.2015Personality and social support as predictors of first and recurrent episodes of depression

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