François Jacob's lab in the seventies: the T-complex and the mouse developmental genetic program.

Michel Morange

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Philosophy and History of Science History of Science and Medicine Developmental Biology and Gene Regulation

Abstract

The existence of a genetic program of development was proposed by molecular biologists in the nineteen-sixties. Historians and philosophers of science have since thoroughly criticized this notion. To fully appreciate its significance, it is interesting to consider the research which was pursued during this period by molecular biologists who proposed this notion. This study focuses on François Jacob's work and on the model of development supported by his lab in the early seventies, the T-complex model. This episode of Jacob's scientific activity has since been forgotten. Characterization of this model shows that the notion of program was used in a metaphoric way and that it did not put any constraint on the work pursued in the lab at that time. Some attention is devoted to the origin of this metaphor in the context of the nineteen-seventies.

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References

1961General Conclusions: Teleonomic Mechanisms in Cellular Metabolism, Growth, and Differentiation 1982The possible and the actual 1998A history of molecular biology 1981Le jeu des possibles 1998Of worms and programmes: Caenorhabditis elegans and the study of development 1997The transformation of molecular biology on contact with higher organisms, 1960-1980: from a molecular description to a molecular explanation.2000Decoding the Genetic Program: Or, Some Circular Logic in the Logic of Circularity

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