Article2001

Olanzapine Augmentation of Serotonin Uptake Inhibitors in Obsessive—Compulsive Disorder: An Open Study

70 citations0/0 files storedThe Canadian Journal of Psychiatry

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Obsessive-Compulsive Spectrum Disorders Psychoanalysis and Psychopathology Research Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Abstract

OBJECTIVE: This study evaluates the clinical response to olanzapine used in association with selective serotonin reuptake inhibitors (SSRIs) or clomipramine in treatment-resistant obsessive-compulsive disorder (OCD). METHODS: We describe the cases of 9 patients with serotonin uptake inhibitor-resistant OCD who were given an open-label adjunctive treatment of olanzapine for a minimum of 6 weeks. The response was assessed by using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Clinical Global Impression Scale (CGI). RESULTS: Six patients showed improvement of symptoms after the augmentation with olanzapine. One patient (treated with clomipramine) discontinued olanzapine due to side effects, and another 2 did not respond. CONCLUSION: Olanzapine augmentation of SSRIs in treating OCD showed a good (two-thirds) response rate, and it could therefore be considered as a treatment option when conventional therapies have failed.

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References

2000A Double-blind, Placebo-Controlled Study of Risperidone Addition in Serotonin Reuptake Inhibitor–Refractory Obsessive-compulsive Disorder 1994Haloperidol Addition in Fluvoxamine-Refractory Obsessive-Compulsive Disorder 1989Efficacy of Fluvoxamine in Obsessive-Compulsive Disorder 1990Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder 1995Lack of efficacy of clozapine monotherapy in refractory obsessive- compulsive disorder 2000Olanzapine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder 1999Olanzapine Addition in Obsessive-Compulsive Disorder Refractory to Selective Serotonin Reuptake Inhibitors 1996Therapeutic effect and safety of adjunctive risperidone in refractory obsessive-compulsive disorder (OCD).

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