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Reports of quantitative experimental results often distinguish between the statistical uncertainty and the systematic uncertainty that characterize measurement outcomes. This article discusses the practice of estimating systematic uncertainty in high-energy physics (HEP). The estimation of systematic uncertainty in HEP should be understood as a minimal form of quantitative robustness analysis. The secure evidence framework is used to explain the epistemic significance of robustness analysis. However, the empirical value of a measurement result depends crucially not only on the resulting systematic uncertainty estimate, but on the learning aims for which that result will be used. Important conceptual and practical questions regarding systematic uncertainty assessment call for further investigation. 1 Introduction2 Systematic Uncertainty: The Very Idea3 Systematic Uncertainty in High-Energy Physics4 Methodological Debates in High-Energy Physics5 The Secure Evidence Framework6 Systematic Uncertainty Assessment as Robustness Analysis7 Security and Sensitivity8 ConclusionAppendix
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