Transfusion Transmitted Infections In Patients With Hemophilia: A Study From A Tertiary Care Hospital In Western India.

Abstract

Transfusion transmitted infections (TTI) continue to endanger safe blood supply. The risk for acquiring TTI is even higher in multiply transfused patients. This study is aimed to estimate the prevalence of TTI in 80 multiply transfused patients of Hemophilia. 80 male patients of hemophilia and 320 normal voluntary blood donors were included in the study. Screening for anti-HIV, HBsAg and anti-HCV was carried out by enzyme linked immunosorbent assay (ELISA). Syphilis was tested using RPR card test. Out of 80 multiply transfused patients, 10 (12.5%) were infected with TTI. Seroreactivity for 7.5% for HCV and 5 % for HBV. No patient was found reactive for HIV and syphilis. In blood donors seroprevalence of viral markers was 0.31% for HCV and HIV, 0.94% for HBV whereas 1.25% donors showed reactive RPR test for syphilis. This study showed that HCV and HBV infection were more frequently identified than HIV in multitransfused hemophiliacs. Promoting voluntary blood donation, adopting sensitive screening methods and use of virally inactivated or recombinant factor concentrate will decrease the prevalence of TTI in people with hemophilia (PWH).

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