Posttraumatic Stress Disorder-Related Cardiovascular Disease and Accelerated Cellular Aging

Erika J. Wolf · Paula P. Schnurr

71 citations0/0 files storedPsychiatric Annals

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Posttraumatic Stress Disorder Research Child Abuse and Trauma Cardiac Health and Mental Health

Abstract

We reviewed the literature from 2010 to 2016 on the relationship between posttraumatic stress disorder (PTSD) and cardiometabolic health conditions, including metabolic syndrome, coronary artery disease, stroke, and myocardial infarction, among others. Collectively, PTSD was associated with increased risk of cardiometabolic health problems, with pre-clinical and clinical studies offering evidence of behavioral (e.g., poor sleep, cigarette use, poor diet and insufficient exercise) and biological (e.g., autonomic reactivity, inflammation) mediators of these associations. We discuss the possibility that these behavioral and biological mechanisms lead to accelerated cellular aging, as regulated in the epigenome, which contributes to premature cardiometabolic health decline. This has implications for the assessment, prevention, and treatment of cardiometabolic conditions among those with PTSD. It also highlights the need to better understand the mechanisms linking PTSD to accelerated aging and to develop interventions to attenuate or reverse this phenomenon.

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References

2013Posttraumatic stress disorder and risk for coronary heart disease: A meta-analytic review 2015Physical activity in the treatment of Post-traumatic stress disorder: A systematic review and meta-analysis 2015Trauma Exposure and Posttraumatic Stress Disorder Symptoms Predict Onset of Cardiovascular Events in Women 2014Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis 2004Understanding relationships among trauma, post-tramatic stress disorder, and health outcomes.2015The prevalence and risk of metabolic syndrome and its components among people with posttraumatic stress disorder: a systematic review and meta-analysis 2015Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature 2004Understanding relationships among trauma, posttraumatic stress disorder, and health outcomes.

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