Using the Research Domain Criteria Framework to Explore Associations Between MMPI–2–RF Constructs and Physiological Variables Assessed by Eye-Tracker Technology

Abstract

The National Institute of Mental Health has proposed a paradigm shift in the conceptualization of psychopathology, abandoning the traditional categorical model in favor of one based on hierarchically organized dimensional constructs (Insel et al., 2010 Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., … Wang, P. (2010). Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. American Journal of Psychiatry, 167, 748–751.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). One explicit goal of this initiative, the Research Domain Criteria (RDoC) project, is to facilitate the incorporation of newly available neurobiologic variables into research on psychopathology. The Minnesota Multiphasic Personality Inventory–2–Restructured Form (MMPI–2–RF; Ben-Porath & Tellegen, 2008/2011 Ben-Porath, Y., & Tellegen, A. (2011). Minnesota Multiphasic Personality Inventory–Restructured Form: Manual for administration, scoring, and interpretation. Minneapolis: University of Minnesota Press. (Original work published 2008) [Google Scholar]) represents a similar paradigm shift, also adopting a hierarchical arrangement of dimensional constructs. This study examined associations between MMPI–2–RF measures of psychopathology and eye-movement metrics. Participants were college students (n = 270) who completed the MMPI–2–RF and then viewed a sequence of 30-s video clips. Results show a pattern of positive correlations between pupil size and emotional/internalizing dysfunction scales when viewing video eliciting negative emotional reactions, reflecting greater arousability in individuals with higher scores on these measures. In contrast, when viewing stimuli depicting angry, threatening material, a clear pattern of negative correlations was found between pupil size and behavioral/externalizing trait measures. These data add to the construct validity of the MMPI–2–RF and support the use of the RDoC matrix as a framework for research on psychopathology.

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