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Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials
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Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials (2017)Suvorexant in Elderly Patients with Insom…Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials (2014)Suvorexant in Patients With I…Sleep in Older Adults (2014)Sleep in Older AdultsSafety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial (2014)Safety and efficacy of suvore…Orexin receptor antagonism for treatment of insomnia (2012)Orexin receptor antagonism fo…Insomnia Pharmacotherapy (2012)Insomnia PharmacotherapyEffectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration (2012)Effectiveness of non-benzodia…The Columbia–Suicide Severity Rating Scale: Initial Validity and Internal Consistency Findings From Three Multisite Studies With Adolescents and Adults (2011)The Columbia–Suicide Severity…Discovery of the Dual Orexin Receptor Antagonist [(7 R )-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2 H -1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia (2010)Discovery of the Dual Orexin …Evidence‐Based Recommendations for the Assessment and Management of Sleep Disorders in Older Persons (2009)Evidence‐Based Recommendation…Diagnostic and Statistical Manual of Mental Disorders (2008)Diagnostic and Statistical Ma…Aging-Related Sleep Changes (2007)Aging-Related Sleep ChangesSedative hypnotics in older people with insomnia: meta-analysis of risks and benefits (2005)Sedative hypnotics in older p…Prevalence and Comorbidity of Insomnia and Effect on Functioning in Elderly Populations (2005)Prevalence and Comorbidity of…Meta-Analysis of Quantitative Sleep Parameters From Childhood to Old Age in Healthy Individuals: Developing Normative Sleep Values Across the Human Lifespan (2004)Meta-Analysis of Quantitative…Sleep Complaints Among Elderly Persons: An Epidemiologic Study of Three Communities (1995)Sleep Complaints Among Elderl…Targeting Orexin Receptors for the Treatment of Insomnia: From Physiological Mechanisms to Current Clinical Evidence and Recommendations (2023)Targeting Orexin Receptors fo…Alliance for Sleep Clinical Practice Guideline on Switching or Deprescribing Hypnotic Medications for Insomnia (2023)Alliance for Sleep Clinical P…The Treatment of Sleep Dysfunction in Neurodegenerative Disorders (2020)The Treatment of Sleep Dysfun…Comparative efficacy and safety of hypnotics for insomnia in older adults: a systematic review and network meta-analysis (2020)Comparative efficacy and safe…Efficacy and safety of non-benzodiazepine and non-Z-drug hypnotic medication for insomnia in older people: a systematic literature review (2019)Efficacy and safety of non-be…Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications (2018)Orexin receptor antagonists f…Making sleep easier: pharmacological interventions for insomnia (2018)Making sleep easier: pharmaco…Clinical practice guideline on management of sleep disorders in the elderly (2018)Clinical practice guideline o…A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale (1991)Epidemiology of insomnia: what we know and what we still need to learn (2002)The American Academy of Sleep Medicine (AASM) Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications (2007)Insomnia Severity Index: psychometric properties with Chinese community‐dwelling older people (2010)Prevalence of Sleep Disturbances in Mild Cognitive Impairment and Dementing Disorders: A Multicenter Italian Clinical Cross-Sectional Study on 431 Patients (2012)Sleep in the Aging Population (2016)ECDEU Assessment Manual for Psychopharmacology (1976)Validation of the Insomnia Severity Index as an outcome measure for insomnia research (2001)Diagnostic and Statistical Manual of Mental Disorders (2013)Review of Safety and Efficacy of Sleep Medicines in Older Adults (2016)S3-Leitlinie Nicht erholsamer Schlaf/Schlafstörungen (2017)Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery (2018)Insomnia and its relationship to health-care utilization, work absenteeism, productivity and accidents (2008)Suvorexant for insomnia: a systematic review of the efficacy and safety profile for this newly approved hypnotic - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? 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References

  • 2008Diagnostic and Statistical Manual of Mental Disorders8,477 cited
  • 2011The Columbia–Suicide Severity Rating Scale: Initial Validity and Internal Consistency Findings From Three Multisite Studies With Adolescents and Adults5,145 cited
  • 2004Meta-Analysis of Quantitative Sleep Parameters From Childhood to Old Age in Healthy Individuals: Developing Normative Sleep Values Across the Human Lifespan3,348 cited
  • 1995Sleep Complaints Among Elderly Persons: An Epidemiologic Study of Three Communities1,610 cited
  • 2005Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits1,158 cited
  • 2014Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial519 cited
  • 2009Evidence‐Based Recommendations for the Assessment and Management of Sleep Disorders in Older Persons464 cited
  • 2010Discovery of the Dual Orexin Receptor Antagonist [(7 R )-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2 H -1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia379 cited
  • 2012Orexin receptor antagonism for treatment of insomnia322 cited
  • 2012Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration313 cited
  • 2014Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials301 cited
  • 2005Prevalence and Comorbidity of Insomnia and Effect on Functioning in Elderly Populations

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282 cited
  • 2007Aging-Related Sleep Changes272 cited
  • 2014Sleep in Older Adults195 cited
  • 2012Insomnia Pharmacotherapy133 cited
  • Cited by

    • 2023Targeting Orexin Receptors for the Treatment of Insomnia: From Physiological Mechanisms to Current Clinical Evidence and Recommendations64 cited
    • 2023Alliance for Sleep Clinical Practice Guideline on Switching or Deprescribing Hypnotic Medications for Insomnia59 cited
    • 2019Efficacy and safety of non-benzodiazepine and non-Z-drug hypnotic medication for insomnia in older people: a systematic literature review54 cited
    • 2018Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications53 cited
    • 2018Making sleep easier: pharmacological interventions for insomnia50 cited
    • 2020The Treatment of Sleep Dysfunction in Neurodegenerative Disorders46 cited
    • 2020Comparative efficacy and safety of hypnotics for insomnia in older adults: a systematic review and network meta-analysis45 cited
    • 2018Clinical practice guideline on management of sleep disorders in the elderly44 cited