In light of the growing national priority to develop and revitalise entrepreneurship in emerging economies, our understanding of barriers to serial entrepreneurship (SE) in such a context warrants further scholarly attention. Using insights from Ghana, an integrated framework of endogenous and exogenous barriers to SE is advanced. The study identified factors such as stigmatisation of business failure, fear of failure, successive governments’ suspicion of the private sector and lack of a clear national policy as barriers to the development of SE. By creating conditions for de-stigmatising of failure, countries would be able to create conditions for more serial entrepreneurs to emerge and flourish. The analysis also indicates that reinvigorating entrepreneurship by providing space and opportunity for failed entrepreneurs to re-emerge would enable such countries to enhance entrepreneurial activities and improve economic development. The implications for technology analysis and strategic entrepreneurship literature are identified and examined.
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