Article1991

Elevated medial-frontal cerebral blood flow in obsessive-compulsive patients: a SPECT study

Steven R. Machlin · Gordon J. Harris · Godfrey D. Pearlson · Rudolf Hoehn‐Saric · Edwaldo E. Camargo

194 citations0/0 files storedAmerican Journal of Psychiatry

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Obsessive-Compulsive Spectrum Disorders Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Neural and Behavioral Psychology Studies

Abstract

Regional cerebral blood flow was measured with single photon emission computed tomography in 10 obsessive-compulsive patients and eight comparison subjects. The patients had a significantly higher ratio of medial-frontal to whole cortex blood flow; this was unrelated to symptom severity but was correlated negatively with anxiety. No differences in orbital-frontal blood flow were found.

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References

1959THE ASSESSMENT OF ANXIETY STATES BY RATING 1987Local Cerebral Glucose Metabolic Rates in Obsessive-Compulsive Disorder 1989Cerebral Glucose Metabolism in Childhood-Onset Obsessive-Compulsive Disorder 1988Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder 1989Cerebral glucose metabolic rates in obsessive compulsive disorder 1983Obsessive-Compulsive Disorder

Cited by

1992Neuroimaging Studies of Obsessive Compulsive Disorder 1997Pathogenesis of Tourette's Syndrome 2006Understanding Obsessive–Compulsive Disorder: Focus on Decision Making 2000A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT)1996A controlled positron emission tomography study of obsessive and neutral auditory stimulation in obsessive-compulsive disorder with checking rituals 2006A diffusion tensor imaging study of white matter in obsessive–compulsive disorder 2008A Psychological and Neuroanatomical Model of Obsessive-Compulsive Disorder

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