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The impact of influenza on the health related quality of life in China: an EQ-5D survey

Juan Yang · Mark Jit · Yaming Zheng · Shuo Feng · Xinxin Liu · Joseph Tsz Kei Wu +1 more

64 citations0/0 files storedBMC Infectious Diseases

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Health Systems, Economic Evaluations, Quality of Life Influenza Virus Research Studies Respiratory viral infections research

Abstract

BACKGROUND: Influenza causes considerable morbidity and mortality in China, but its impact on the health-related quality of life (HRQoL) has not been previously measured. METHODS: We conducted a retrospective telephone survey to assess the impact of influenza on the HRQoL among outpatients and inpatients using the EuroQoL EQ-5D-3 L instrument. Participants were individuals with laboratory-confirmed influenza infection registered by the National Influenza-like-illness Surveillance Network in 2013. RESULTS: We interviewed 839 of 11,098 eligible influenza patients. After excluding those who were unable to complete the HRQoL for the registered influenza episode, 778 patients were included in the analysis. Both outpatients (n = 529) and inpatients (n = 249) most commonly reported problems with pain/discomfort (71.8% of outpatients and 71.9% of inpatients) and anxiety/depression (62.0% of outpatients and 75.1% of inpatients). For individual influenza outpatients, the mean health utility was 0.6142 (SD 0.2006), and the average quality adjusted life days (QALD) loss was 1.62 (SD 1.84) days. The HRQoL of influenza inpatients was worse (mean health utility 0.5851, SD 0.2197; mean QALD loss 3.51 days, SD 4.25) than that of outpatients (p < 0.05). The presence of underlying medical conditions lowered the HRQoL for both outpatients and inpatients (p < 0.05). CONCLUSIONS: Influenza illness had a substantial impact on HRQoL. QALD loss due to an acute influenza episode in younger children was comparable to that due to enterovirus A71-associated hand, foot and mouth disease. Our findings are key inputs into disease burden estimates and cost-effectiveness evaluations of influenza-related interventions in China.

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1990EuroQol - a new facility for the measurement of health-related quality of life 2013Pediatric Patient-Reported Outcome Instruments for Research to Support Medical Product Labeling: Report of the ISPOR PRO Good Research Practices for the Assessment of Children and Adolescents Task Force 2014Chinese Time Trade-Off Values for EQ-5D Health States 2009Utilities of the EQ-5D 2014Comparison between the EQ-5D-5L and the EQ-5D-3L in patients with hepatitis B 2011EQ-5D for the Assessment of Health-Related Quality of Life and Resource Allocation in Children: A Systematic Methodological Review 2010Preliminary findings of an investigation into the relationship between national culture and EQ-5D value sets 2015Valuing Health-Related Quality of Life in Type 2 Diabetes Patients in China

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