High-Intensity Interval Training Attenuates Insulin Resistance Induced by Sleep Deprivation in Healthy Males

Jorge Fernando Tavares de Souza · Murilo Dattilo · Marco Túlio de Mello · Sérgio Tufik · Hanna Karen Moreira Antunes

35 citations0/0 files storedFrontiers in Physiology

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Sleep and Work-Related Fatigue Sleep and related disorders Circadian rhythm and melatonin

Abstract

Introduction: Sleep deprivation can impair several physiological systems and recently, new evidence has pointed to the relationship between a lack of sleep and carbohydrate metabolism, consequently resulting in insulin resistance. To minimize this effect, High-Intensity Interval Training (HIIT) is emerging as a potential strategy. Objective: The aim of this study was to investigate the effects of HIIT on insulin resistance induced by sleep deprivation. Method: 11 healthy male volunteers were recruited, aged 18-35 years, who declared taking 7-8 h sleep per night. All volunteers were submitted to four different conditions: a single night of regular sleep (RS condition), 24 hours of total sleep deprivation (SD condition), HIIT training followed by regular sleep (HIIT+RS condition), and HIIT training followed by 24 hours of total sleep deprivation (HIIT+SD condition). They performed six training sessions over 2 weeks and each session consisted of 8-12 x 60s intervals at 100% of peak power output. In each experimental condition, tests for glucose, insulin, cortisol, free fatty acids, and insulin sensitivity, measured by oral glucose tolerance test (OGTT), were performed. Results: Sleep deprivation increased glycaemia and insulin levels, as well as the area under the curve. Furthermore, an increase in free fatty acids concentrations and basal metabolism was observed. There were no differences in the concentrations of cortisol. However, HIIT before 24 hours of sleep deprivation attenuated the increase of glucose, insulin and free fatty acids. Conclusion: 24 hours of sleep deprivation resulted in acute insulin resistance. However, HIIT is an effective strategy to minimize the deleterious effects promoted by this condition.

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1999Impact of sleep debt on metabolic and endocrine function 2007The metabolic consequences of sleep deprivation 2010Validation of the Brazilian Portuguese version of the Pittsburgh Sleep Quality Index 2010Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men 2010A Single Night of Partial Sleep Deprivation Induces Insulin Resistance in Multiple Metabolic Pathways in Healthy Subjects 2012Impaired Insulin Signaling in Human Adipocytes After Experimental Sleep Restriction 2009Exposure to Recurrent Sleep Restriction in the Setting of High Caloric Intake and Physical Inactivity Results in Increased Insulin Resistance and Reduced Glucose Tolerance 2015Sleep restriction increases free fatty acids in healthy men

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