Modeling Agreement between Binary Classifications of Multiple Raters in R and SAS

Abstract

Cancer screening and diagnostic tests often are classified using a binary outcome such as diseased or not diseased. Recently large-scale studies have been conducted to assess agreement between many raters. Measures of agreement using the class of generalized linear mixed models were implemented efficiently in four recently introduced R and SAS packages in large-scale agreement studies incorporating binary classifications. Simulation studies were conducted to compare the performance across the packages and apply the agreement methods to two cancer studies.

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