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Background: Workers performance is the foundation for the development of an organization. Creating favorable working environment is fundamental to advance workers performance. Thus, the study was intended to measure level of work performance and to identify associated factors among workers in Amhara national regional state health bureau.Methods: Across-sectional study design was employed among 357 employees. Data were collected using self-administrated structured questionnaires. It was entered in to Epi-info version 3.5.1 and analyzed using SPSS. Descriptive statistics was computed to summarize the result and represented by tables. Binary logistic regression was calculated to explore the relation between the predictors and outcome variable. Multivariate logistic regression model with 95% C.I. was also computed to determine the independent association of factors with work performance.Results: The level of work performance was 76.64% (76.25-77.03). The majority of the employees' performance level found to be good. Salary [AOR=3.94 (1.41, 10.99)], years of working [AOR=3.07 (1.25, 7.49)], type of working department [AOR=6.77 (2.57, 17.79)] and type of work [AOR=0.32 (0.13, 0.77)] were independently predicting level of work performance.Conclusion: The level of performance was comparable to other studies in similar settings. Encouraging employees with reasonable salary based on work experience and availing conducive work structure should be given due attention by the health bureau to have better organizational performance for development.
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