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Background: Spirituality and its effect on people’s health are attended more than before. The current study was conducted to determine the relationship between spiritual well-being, hopelessness, and self-efficacy component in the students of Isfahan University of Medical Sciences. Objectives: The current study aimed at Investigate the relationship between spiritual health and hopelessness to Self-efficacy in students of Isfahan University of Medical Sciences. Methods: The current descriptive-correlational study was conducted in 2014 on 175 students selected from Isfahan University of Medical Sciences. The data were collected via demographic characteristics, spirituality well-being, hopelessness, and self-efficacy questionnaires; the significant level was considered < 0.05. Results: A total of 175 students including 75 males and 100 females participated in the study. There was a significant and revers relationship between spiritual well-being and hopelessness among the subjects (R = - 0.632; P < 0.0001). Conclusions: In the current study, spiritual well-being had a direct relationship with self-efficacy and revers relationship with hopelessness. It is offered to make arrangement in order to promote self-efficacy and reduce hopelessness in students.
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