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In contemporary studies, three texts dating from the second half of the sixteenth century continue to be treated as essential primary literature concerning pre-Hispanic and early colonial medicine. These are the herbalLibellus de medicinalibus indorum herbis(1552), composed by the Nahuas Martín de la Cruz and Juan Badiano in the Imperial College of Santa Cruz of Tlatelolco; theHistoria natural de Nueva España, written by Philip II'sprotomédico(royal physician) Francisco Hernández, a “scientific envoy” in New Spain in the 1570s; and theFlorentine Codex, the only extant manuscript of the 12-book encyclopedia on the world of the Nahuas,Historia universal de las cosas de Nueva España(ca. 1577), which was directed by Fray Bernardino de Sahagún.
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