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Seeking to build an objective scientific approach to psychiatry, American psychiatrists, physiologists, and psychologists began to turn to the conditional reflex method of Ivan Pavlov from the late 1920s. The generation of “neurotic” animals in the laboratory was critical to the emergence of a new experimental psychiatry in the United States. To understand the development of this field of research, the chapter will draw first on Mary Morgan’s identification of the mediatory and intermediary role of models and their ability to surprise and generate new questions, and second, upon her recent work on narratives in science. It will argue that it was through discursive and descriptive techniques that traced over time the tangled and interconnected lives of experimental subjects, that such elements of unpredictability in the animal laboratory were transformed into tools of research and put to disciplinary uses, promoting the clinical relevance of this new objective approach to psychiatric medicine.
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