Reviewhybrid2018

Robust Findings From 25 Years of PTSD Genetics Research

Laramie E. Duncan · Bryna N. Cooper · Hanyang Shen

63 citations0/0 files storedCurrent Psychiatry Reports

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Posttraumatic Stress Disorder Research Genetic Associations and Epidemiology Neurotransmitter Receptor Influence on Behavior

Abstract

PURPOSE OF REVIEW: The purpose of this review is to contextualize findings from the first 25 years of PTSD genetics research, focusing on the most robust findings and interpreting results in light of principles that have emerged from modern genetics studies. RECENT FINDINGS: Genome-wide association studies (GWAS) encompassing tens of thousands of participants enabled the first molecular genetic heritability and genetic correlation estimates for PTSD in 2017. In 2018, highly promising loci for PTSD were reported, including variants in and near the CAMKV, KANSL1, and TCF4 genes. Twin studies from 25 years ago established that PTSD is genetically influenced and foreshadowed the molecular genetic findings of today. Discoveries that were impossible with smaller studies have been achieved via collaborative/team-science efforts. Most promisingly, individual genomic loci offer entirely novel clues about PTSD etiology, providing the raw material for transformative discoveries, and the future of PTSD research is bright.

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References

2013Diagnostic and Statistical Manual of Mental Disorders 2005Why Most Published Research Findings Are False 2000Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults.2005Why Most Published Research Findings Are False 1983How People Make Their Own Environments: A Theory of Genotype Environment Effects 2011Gender differences in anxiety disorders: Prevalence, course of illness, comorbidity and burden of illness 2006Sex differences in trauma and posttraumatic stress disorder: A quantitative review of 25 years of research.2013National Estimates of Exposure to Traumatic Events and PTSD Prevalence Using DSM-IV and DSM-5 Criteria

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