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An Optimization-Based Framework to Define the Probabilistic Design Space of Pharmaceutical Processes with Model Uncertainty

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References

2009Quality by design case study: An integrated multivariate approach to drug product and process development214 cited
2008A Bayesian Approach to the ICH Q8 Definition of Design Space141 cited
2008The Use of Routine Process Capability for the Determination of Process Parameter Criticality in Small-molecule API Synthesis24 cited

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2019Computationally efficient identification of probabilistic design spaces through application of metamodeling and adaptive sampling43 cited

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