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Summary Parametric uncertainties complicate engineering design—confounding regulated design approaches and degrading the performance of reliability efforts. The simplest means to tackle this uncertainty is double‐loop simulation, a nested Monte Carlo method that, for practical problems, is intractable. In this work, we introduce a flexible, general approximation technique that obviates the double loop. This approximation is constructed in the context of a novel theory of reliability design under parametric uncertainty: we introduce metrics for measuring the efficacy of reliability‐based design optimization strategies (epistemic design gap and effective reliability), minimal conditions for controlling uncertain reliability (precision margin), and stricter conditions that guarantee the desired reliability at a designed confidence level. We provide a number of examples with open‐source code to demonstrate our approaches in a reproducible fashion.
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