Articlehybrid2019

Four-year course of quality of life and obsessive–compulsive disorder

Karin C.P. Remmerswaal · Neeltje M. Batelaan · Adriaan W. Hoogendoorn · Nic J.A. van der Wee · Patricia van Oppen · Anton J.L.M. van Balkom

62 citations0/0 files storedSocial Psychiatry and Psychiatric Epidemiology

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Obsessive-Compulsive Spectrum Disorders Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Perfectionism, Procrastination, Anxiety Studies

Abstract

OBJECTIVE: Patients with obsessive compulsive disorder (OCD) have high disease burden. It is important to restore quality of life (QoL) in treatment, so that patients become able to live a fulfilling life. Little is known about the longitudinal course of QoL in patients with OCD, its association with remission from OCD, and about factors that contribute to an unfavourable course of QoL in remitting patients. METHODS: Study on the 4-year course of QoL of patients with chronic (n = 144), intermittent (n = 22), and remitting OCD (n = 73) using longitudinal data of the Netherlands Obsessive Compulsive Disorder Association (NOCDA; complete data: n = 239; imputed data n = 382). The EuroQol five-dimensional questionnaire (EQ-5D) utility score was used to assess QoL. In patients with remitting OCD, we examined patient characteristics that contributed to an unfavourable course of QoL, including sociodemographics, OCD characteristics, psychiatric comorbidity, and personality traits. RESULTS: Course of QoL was associated with course of OCD. QoL improved in those who remitted from OCD; however, even in these patients, QoL remained significantly below the population norms. The correlation between QoL and severity of OCD was only moderate: r = - 0.40 indicating that other factors besides OCD severity contribute to QoL. In remitters, more severe anxiety and depression symptoms were related to a lower QoL. Results were similar in complete and imputed data sets. CONCLUSIONS: Remission from OCD is associated with improvement of QoL, but comorbid anxiety and depression symptoms hamper the improvement of QoL. QoL could be improved by reducing OCD symptoms in patients with OCD and by treating comorbid anxiety and depression symptoms in remitting patients.

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References

1990EuroQol - a new facility for the measurement of health-related quality of life 1988An inventory for measuring clinical anxiety: Psychometric properties.1988Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation 1989The Yale-Brown Obsessive Compulsive Scale 1989The Yale-Brown Obsessive Compulsive Scale 1994The Yale-Brown Obsessive-Compulsive Scale: Measures of internal consistency 1993Quality of Life Enjoyment and Satisfaction Questionnaire: a new measure.2008Refining the relationship between personality and subjective well-being.

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