Scientific discourse in the era of open science: a response to Hall et al. regarding the Carbohydrate-Insulin Model

Abstract

In November 2018, we presented the results of a large macronutrient feeding study at The Obesity Society’s Blackburn Symposium [ 1 ] and simultaneously in BMJ, with peer review available online [ 2 ]. In that study, total energy expenditure (TEE) measured by doubly-labeled water (DLW) at post-weight-loss and at 10 and 20 weeks of weight-loss maintenance was 200–280 kcal/day greater on a low- versus high-carbohydrate diet, consistent with the Carbohydrate-Insulin Model of obesity [ 3 ]. To facilitate scientific discourse, we made the full database immediately available on Open Science Framework.

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