Interventions to Increase Completion of Hepatitis B Vaccination in People who Inject Drugs: A Systematic Review and Meta-analysis

Stacy R. Tressler · Ruchi Bhandari

43 citations0/0 files storedOpen Forum Infectious Diseases

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Vaccine Coverage and Hesitancy Hepatitis B Virus Studies Intramuscular injections and effects

Abstract

Increases in opioid misuse and injection drug use have resulted in a rise in acute cases of hepatitis B. We conducted a systematic review and meta-analysis of randomized studies to determine the effect (pooled odds ratio) of interventions to increase hepatitis B vaccination completion in people who inject drugs (PWID). Odds ratios from the included studies were combined to create a pooled odds ratio (OR) using the Inverse Heterogeneity Model. Eleven studies met the eligibility criterion of having a randomized intervention to increase hepatitis B virus vaccination completion among PWID. The odds of vaccine completion in the intervention group were greater than in the control/comparison group (pooled OR, 2.53; 95% confidence interval [CI], 1.07-5.99). Subgroup analysis indicated that financial incentives were most effective (OR, 7.01; 95% CI, 2.88-17.06), followed by accelerated vaccine schedules (OR, 1.90; 95% CI, 1.14-3.14). Interventions using financial incentives and accelerated vaccine schedules are moderately effective at increasing hepatitis B vaccination completion in PWID.

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References

2008Cochrane Handbook for Systematic Reviews of Interventions 2010Cochrane Handbook for Systematic Reviews of Interventions 2009Epidemiology and Prevention of Vaccine-Preventable Diseases 2003A randomized controlled trial of monetary incentives vs. outreach to enhance adherence to the hepatitis B vaccine series among injection drug users 2013A randomised controlled trial of financial incentives to increase hepatitis B vaccination completion among people who inject drugs in Australia 2015Nursing Case Management, Peer Coaching, and Hepatitis A and B Vaccine Completion Among Homeless Men Recently Released on Parole

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