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This paper provides an overview of regional science research in the Netherlands since the 1960s. It adopts a contextual thematic approach in identifying and interpreting regional science research topics, practices and methodologies, inspired by Toynbee's challenge and response concept. It argues that place-based, cultural and historical conditions in the Netherlands have prompted a pragmatic and evidence-based scientific approach, in which in particular an innovative quantitative orientation accompanied by a methodological heterogeneity has given Dutch regional science a high international profile. Over the past decades, numerous regional scientists in the country have contributed to this achievement, too many to be mentioned in this overview. This paper has its limitations and offers mainly thematic examples of original—often quantitative—research undertaken by various Dutch regional scientists, that make a difference compared to general approaches in Europe and world-wide. From our concise review we conclude that – despite the small size of the country – the challenge and creative response model of Dutch regional science has been rather successful.
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