Articlegreen2019

Clinical characteristics of late-life depression predicting mortality

Karen S. van den Berg · Carlijn Wiersema · J.M. Hegeman · Rob H. S. van den Brink · Didi Rhebergen · Radboud M. Marijnissen +1 more

49 citations0/0 files storedAging & Mental Health

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Mental Health Treatment and Access Aging, Health, and Disability Health disparities and outcomes

Abstract

Objective Depression has been associated with increased mortality rates, and modifying mechanisms have not yet been elucidated. We examined whether specific subtypes or characteristics of late-life depression predict mortality.Methods A cohort study including 378 depressed older patients according to DSM-IV criteria and 132 never depressed comparisons. The predictive value of depression subtypes and characteristics on the six-year mortality rate, as well as their interaction with somatic disease burden and antidepressant drug use, were studied by Cox proportional hazard analysis adjusted for demographic and lifestyle characteristics.Results Depressed persons had a higher mortality risk than non-depressed comparisons (HR = 2.95 [95% CI: 1.41–6.16], p = .004), which lost significance after adjustment for age, sex, education, smoking, alcohol, physical activity, number of prescribed medications and somatic comorbidity. Regarding depression subtypes and characteristics, only minor depression was associated with a higher mortality risk when adjusted for confounders (HR = 6.59 [95% CI: 1.79–24.2], p = .005).Conclusions Increased mortality rates of depressed older persons seem best explained by unhealthy lifestyle characteristics and multiple drug prescriptions. The high mortality rate in minor depression, independent of these factors, might point to another, yet unknown, pathway towards mortality for this depression subtype. An explanation might be that minor depression in later life reflects depressive symptoms due to underlying aging-related processes, such as inflammation-based sickness behavior, frailty, and mild cognitive impairment, which have all been associated with increased mortality.

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References

2015Mortality in Mental Disorders and Global Disease Burden Implications 1996The Inventory of Depressive Symptomatology (IDS): psychometric properties 2002Excess mortality in depression: a meta-analysis of community studies 2014Comprehensive Meta-Analysis of Excess Mortality in Depression in the General Community Versus Patients With Specific Illnesses 2013Differential mortality rates in major and subthreshold depression: meta-analysis of studies that measured both 2001Depression, depressive symptoms and mortality in persons aged 65 and over living in the community: a systematic review of the literature 2008Late-life depression and mortality: influence of gender and antidepressant use 2010Depression, Antidepressant Use and Mortality in Later Life: The Health in Men Study

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