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The current study seeks to investigate the impact of hope and self-efficacy on perceived stress through the mediating role of resilience among Iranian female patients diagnosed with breast cancer. Structural Equation Modeling (SEM) was employed to investigate a mediation model of perceived stress among 227 Iranian female patients undergoing cancer treatment at Omid Hospital in Esfahan, Iran. The results indicated that; (a) Hope and self-efficacy negatively impact perceived stress, (b) Resilience partially mediates the association between hope and perceived stress as well as self-efficacy and perceived stress. In sum, patients with high levels of hope and self-efficacy were more likely to report a greater level of resilience and subsequently report lower perceived stress. These findings indicate that the promotion of resilience, along with hope and self-efficacy enhancements may contribute to decreased levels of perceived stress in breast cancer patients. We discuss how these findings can inform future psychological practice in healthcare.
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