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administered for the same age groups was 16 146 (1648), 1330 (408), and 1529 (623), respectively.This equates to a drop in mean immunization rate between time periods of 31% for individuals aged 0 to 2 years, 78% for those aged 3 to 9 years, and 82% for those aged 10 to 17 years.All age groups had a significant drop in immunizations immediately following social distance guidance release (March 15, 2020).In individuals aged 0 to 2 years, the rate of immunizations dropped by 4581 (95% CI, 2965-6196) immunizations per week (P<.001).In individuals aged 3 to 9 years, it dropped by 2486 (95% CI, 568-4408) immunizations per week (P > .99),and in individuals aged 10 to 17 years, it dropped by 4060 (95% CI, 2156-5965) immunizations per week (P<.001)(Figure 1).While the pre-social distancing trend was declining by 405 (95% CI, 203-607) immunizations per week, the post-social distancing trends were not significant for all age categories.Trends were similar for Haemophilus influenzae type b; 13-valent pneumococcal conjugate; and measles, mumps and rubella vaccines (Figure 2).Discussion | Since the onset of the COVID-19 pandemic, vaccination uptake in children and adolescents has shown a significant decrease in Colorado.While the clinical implications of our observation are not yet known, public health advocates should consider addressing this drop to avoid the potential for vaccine-preventable diseases.Primary care professionals should consider implementing reminders and recalls to parents, 3 and local and state health departments should consider implementing immunization registry-based recall.4 Limitations of this report include its ecological nature, being limited to a single state, and the potential for missing data.
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