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In this paper we present the agent-based model of the Russian Federation spatial development as a tool for simulation of business projects in key industries and their impact on the regional economy. The model interface is used to define the region and industries for each project, as well as structure of its co-financing by organizations, federal and regional budget. Within the algorithm of the project realization the plan of investment supplies is determined, supplementary processes of the organization are simulated and reflected in the accounting. Within the computational experiment results of business projects realization in various regions were studied. The experimental program includes four regions from different federal districts. In each region, three key industries were selected according to perspective economic specializations defined in the Strategy of the Russian Federation spatial development. The results show significant increase in the output, property and equipment of the organizations, and also in employment and income of population in the selected regions.
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