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ABSTRACT The belief that nuclei arose by exogeny, without relation to pre-existent nuclei, was due mostly to Schleiden (1838). Kôlliker (1843) supposed that new nuclei arose by endogeny within pre-existent nuclei. Other early theories of the origin of nuclei contained a considerable element of truth. Many early workers thought that the ordinary nuclei of many-celled plants and animals multiplied by division (Bagge, 1841 ; Nageli, 1844; von Baer, 1846), or by the disappearance of the old nucleus and its immediate replacement by two new ones (Nageli, 1841 ; Reichert, 1846). The history of the discovery of mitosis falls into three parts.
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