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The author, analysing scientific publications in the economic literature on the problem of self-development of regions in Russia over thirty years, determines the dynamics of the growth and decline of researchers' interest in the problem.The result of the analysis resulted in the conclusions: first, the interest in the issue intensified since the early nineties of the last century under the influence of the main storylines for the system of perestroika, the democratisation of the economy, have declined to date to a minimum; secondly, the decision problems are not only not held, but rather worsened -the number of economically insolvent regions increased five times.Stating an objective necessity of conditions creation for transition regions to the self-development mode, the paper presents arguments that define the main factor impeding the regions' self-developmentthe refusal of the Federal Centre from the economy democratisation, the power and development resources centralisation, depriving the regions' opportunities to a diversity of the economy.Another counteraction factor is the weakness of the methodological foundations for stimulating self-development.The main reason is the lack of identification of the definition of the region selfdevelopment concept from the concepts of territorial development and sustainable development of the region, leaving aside the study of the causes and driving forces of self-development presented.In the article: author's formulation of the essence of the region self-development, the criteria for defining the region of self-developing, the main directions and measures for the transition regions on the mode of self-development.
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