Adverse childhood experiences, daytime salivary cortisol, and depressive symptoms in early adulthood: a longitudinal genetically informed twin study

Eleonora Iob · Jessie R. Baldwin · Robert J. Plomin · Andrew Steptoe

52 citations0/0 files storedTranslational Psychiatry

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Child Abuse and Trauma Child and Adolescent Psychosocial and Emotional Development Stress Responses and Cortisol

Abstract

Dysregulated hypothalamic-pituitary-adrenal (HPA)-axis function might underlie the relationship between adverse childhood experiences (ACEs) and depression. However, limited research has examined the possible mediating role of the HPA-axis among young people using longitudinal data. Moreover, it remains unclear whether genetic influences could contribute to these associations. Participants were 290 children from the Twins Early Development Study. ACEs were assessed from age 3-11 years. We calculated a cumulative risk score and also derived different ACEs clusters using factor analysis and latent class analysis. HPA-axis activity was indexed by daytime salivary cortisol at age 11. Depressive symptoms were ascertained at age 21. Genetic liability to altered cortisol levels and elevated depressive symptoms was measured using a twin-based method. We performed causal mediation analysis with mixed-effects regression models. The results showed that ACEs cumulative exposure (b = -0.20, p = 0.03), bullying (b = -0.61, p = 0.01), and emotional abuse (b = -0.84, p = 0.02) were associated with lower cortisol levels at age 11. Among participants exposed to multiple ACEs, lower cortisol was related to higher depressive symptoms at age 21 (b = -0.56, p = 0.05). Lower cortisol levels mediated around 10-20% of the total associations of ACEs cumulative exposure, bullying, and dysfunctional parenting/emotional abuse with higher depressive symptoms. Genetic factors contributed to these associations, but the mediation effects of cortisol in the associations of ACEs cumulative exposure (b = 0.16 [0.02-0.34]) and bullying (b = 0.18 [0.01-0.43]) remained when genetic confounding was accounted for. In conclusion, ACEs were linked to elevated depressive symptoms in early adulthood partly through lower cortisol levels in early adolescence, and these relationships were independent of genetic confounding.

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2012lavaan : An R Package for Structural Equation Modeling 2017The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis 2011Adverse childhood experiences, allostasis, allostatic load, and age-related disease 1995Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents.2004The interrelatedness of multiple forms of childhood abuse, neglect, and household dysfunction 2011poLCA : An R Package for Polytomous Variable Latent Class Analysis 2018Prevalence of Adverse Childhood Experiences From the 2011-2014 Behavioral Risk Factor Surveillance System in 23 States 2019Agreement Between Prospective and Retrospective Measures of Childhood Maltreatment

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