Prioritising breast cancer theranostics: A current medical longing in oncology

Abstract

The Theranostics approach has full potential to completely transform the contemporary medicine system to a patient-centric approach, as it is emerging in quite efficient manner, over the past few years. The primary impetus of this review is to analyse the patent growth in the domain of breast cancer theranostics. This wholesome analysis provides an insight into the current technological and R & D advancement over the years, in breast cancer theranostics. Thus, guide the end-users in getting the conclusion for policymaking and other public recommendations. This patent assessment also foretells about the future trends to carry out further achievements. Due to their easy availability, information richness, & versatility, patent's role in R&D policy has been emphasized by stake holders of innovation including scientists time to time. Graphical Abstract: The figure illustrates the applied technologies used for breast cancer theranostics by top three forward cited patents (A) The oligonucleotides with specific sequences (comprised of at least one of DNA, RNA, PNA. LNA, UNA or combination)1 are capable of binding a targeted tumor protein (PARP1, HISTIHIB, HISTIHID, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, forming a tumor protein complex or subunit or their fragments and might block the tumoral activity. These are also capable of binding to Ramos cells (Derived from Human Burkitt's lymphoma that is negative for Epstein Barr virus). These can also bind cell surface nucleolin and may inhibit cell proliferation. These molecules with detection agent detect the presence or level of disease specific protein. (B) These aptamers with chemical functionalization can be conjugated to an amine linker or high molecular weight non-immunogenic compound or a drug or cytotoxic moiety or labelled with fluorescent agent. These chemically modified aptamers can also bind disease - specific biomarkers e.g., circulating biomarkers, micro- vesicle surface antigens or their functional fragments and can be subsequently used for early diagnosis, prognosis or therapeutic purposes. 1PNA: Peptide Nucleic Acid. LNA: Locked Nucleic Acid. UNA: Unlocked Nucleic Acid

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