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INTRODUCTION: Religious vaccine exemptions are widely available and increasing despite decreases in American religiosity. We tested associations between religion, religiosity, and caregiver vaccine hesitancy in a sample of caregivers of 2-year-olds. METHODS: We analyzed data from a 2020 survey in three pediatric clinics, estimating distinct multivariable logistic regression models to examine associations. RESULTS: Our sample included 255 predominantly poor, Latino, Christian, and English-speaking caregivers (response rate: 90%); 13% were vaccine hesitant. Caregivers identifying with major faith traditions were not more likely to be hesitant than those without a tradition (adjusted odds ratio 1.46; 95% CI 0.29, 7.26). There were no significant associations between caregiver vaccine hesitancy and three religiosity domains. CONCLUSIONS: We found no associations between parental vaccine hesitancy, religiosity, or adherence to a major faith tradition in a sample of mostly poor, Latino, Christian mothers. Additional work is needed to inform exemption policies and public health and faith leaders.
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