This chapter focuses on technology-related ownership changes between large and small high-technology firms. These include the spin-off of new Small and Medium Sized Enterprise (SME) from large firms, intermediate links between large and small firms, and large firm acquisition of technology-intensive SMEs. The chapter analyses patterns of large firm-small firm linkages, collaboration and ownership changes in the 10 European regions studied by the network. It argues that the entrepreneurial spin-offs concept is subdivided with respect to the latest employer: 'main incubator' or 'spin-off parent'. The chapter describes the interaction between large and small technology-intensive European firms. Empirical evidence from research by members of the Targeted Socio-Economic Research European network will be used to consider the questions. The questions are related to concepts like high-technology regions and industries; local technology-intensive SMEs; and a link between regional high-technology clusters and networks.
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