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Identification of threshold for large (dramatic) effects that would obviate randomized trials is not possible

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References

2005Why Most Published Research Findings Are False10,571 cited
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2013Are your data really Pareto distributed?95 cited
2020On single point forecasts for fat-tailed variables66 cited
2016Very large treatment effects in randomised trials as an empirical marker to indicate whether subsequent trials are necessary: meta-epidemiological assessment44 cited
2021An umbrella review of effect size, bias, and power across meta‐analyses in emergency medicine13 cited

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2024Availability of evidence and comparative effectiveness for surgical versus drug interventions: an overview of systematic reviews and meta-analyses5 cited

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