Abstract Quadruple and Quintuple Helix Innovation Systems aim to optimize the design and operation of modern, democratic societies and economies in a smart, sustainable, inclusive, resilient and efficacious manner via the cyber-physical ecosystems that align with Industry 5.0 and Society 5.0 precepts. In this context, the Quintuple Innovation Helix Framework (which is part of the Quadruple/Quintuple Innovation Helix or Q2IH) represents the most comprehensive, meaningful and valuable construct and modality as it encompasses the five key core dimensions of modern, sustainable and democratic knowledge economies and societies. These are the Environment, the Civil Society as well as the Government, University and Industry dimensions. We strongly feel that it is appropriate and even critical, given current events in Europe that starkly highlight the conflict and struggle between democracies and autocracies, to enable, facilitate and even accelerate the further development of an Emerging Unified Theory of Helical Architectures (EUTOHA). The objective would be to bring clarity, coherence and consistency to the process of leveraging the helical architectures to advance and enhance the design of solutions for the digital transformation of modern knowledge economies and societies towards more democratic and sustainable (green) ones.
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