Abstract Quadruple collaboration has risen rapidly in place of the traditional triple helix model of institutional collaboration between universities, governments, and companies. Loet Leydesdorff and Helen Lawton Smith (2022) approach this challenge by aiming to resolve the issue of evaluating and analyzing various quadruple and n-tuple helices. This article seeks to recognize the increasing complexity of new and developing issues in quadruple and n-tuple helices as a response to their research. Higher order helices raise a number of important scientific difficulties, including conceptual and practical issues. The goal of this contribution is to highlight some of the major challenges involved with researching multiple helixes in terms of knowledge innovation, as well as to offer some alternative areas for future research on n-tuple helices measurement.
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