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The analysis of bone age estimations performed by radiological and ultrasonic methods in children aged between 7–17 years. In the paediatric practice skeletal development estimation is a useful tool to examine the level of growth abnormality in the diagnosis and the analysis of the medical treatment effectiveness of children with constitutional delay of growth, growth hormone deficiency, hypothyroidism and other severe chronic illnesses that have significant influence on linear growth. Skeletal maturity of living children is commonly is assessed by using Greulich–Pyle (GP) and Tanner–Whitehouse methods (TW) in the clinical practice in the diagnostic radiography. However, an ultrasonic method was suggested to use in the epidemiological studies of skeletal maturity from the beginning of the 2000s. The aim of the study were to analyse the skeletal maturity estimations of GP, TW2 and TW3 methods by a meta-analysis of former bone age studies and by a comparison of radiological bone estimates; as well as to analyse the accuracy of an ultrasonic method (based on the GP estimation) compared to the GP standard radiographic method. Bone age of healthy children (n: 1648, aged between 7 and 17 years) was estimated by a quantitative ultrasonic Sunlight BoneAge device. In addition, TW2, TW3 and GP bone ages were estimated from radiographs taken from the left wrist-hand region in a randomly selected subsample (n: 47) of subjects. Meta-analysis of radiological skeletal age assessments from the late 1950s was done including the present study. The TW2 and TW3 skeletal age estimations differed from the chronological age of 11 years in the boys and from the beginning of studied age interval in the girls. The GP method showed very strong correlation with both the TW3 RUS and TW3 CA bone age estimations. The CA estimates had a significant decreasing tendency with GP estimates by chronological age in both genders due to the special pattern of carpal maturation. The ultrasonic bone age estimation is suggested to use between the chronological ages 8.5–16 years in the boys and 7.5–15 years in the girls. The very strong correlation of radiological and ultrasonic bone age estimates gives us the possibility to use the ultrasonic bone age estimation in epidemiological surveys to assess skeletal maturity in children without the use of ionizing radiation.
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