The Cochrane Collaboration

Abstract

Abstract For all but the last 100 years, decisions on how to treat patients were almost always based on personal experience, anecdotal case histories, and comparisons of a group of patients who received one treatment with an entirely separate group who did not. These processes, although subject to many biases, are still in use today, but ways to minimize these biases are now available, accepted, and more easily adopted. Among these methods is the use of the randomized trial as a means of providing more reliable estimates of the relative effects of interventions, as the only difference between the patients in the groups being compared in a randomized trial will be that of most interest: namely, the interventions under investigation. The Cochrane Collaboration, which is the subject of this article, was formed to research and assemble a database of relevant trials to fill this void.

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