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The present research investigates the possible causes of resistance to vaccination against the COVID-19 virus. A significant percentage of different countries' populations is refractory to being vaccinated (i.e., in October 2021, in Italy, 20% aged 40-50 years old). A 92-item questionnaire was filled in by a sample of 613 subjects, of which 50.4% said they were against COVID-19 vaccines (63.1% female). Guided by the hypothesis that emotionality constitutes a basis of pre-reflective judgment, items relating to fear, anger and anguish were introduced in the survey. The subjects compiled the Difficulties in Emotional Regulation Scale. The differences between the means of the two samples evaluated with the Student test show that it is, above all, the underlying anguish that constitutes the primary discriminant between the two samples. No Vax mainly considers external the sources of anguish, while Yes Vax sources of anguish appear more internal. From this result an interpretation is advanced: it seems more difficult for No Vax to trust authority recommendations/obligations to get vaccinated because anguish is located just outside the one's body, where Authority dominates. Supplementary Information: The online version contains supplementary material available at 10.1007/s44202-022-00038-2.
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