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BackgroundMultiple health behaviour change (MHBC) interventions are proposed to be an effective and efficient way of intervening to manage and/or prevent chronic conditions, both with patients (targeting health-related behaviours, e.g. diet, smoking) and healthcare professionals (targeting clinical behaviours, e.g. advice, examine). However, their effectiveness is still unclear. Therefore, a review of these interventions in this context is warranted. Two interrelated systematic reviews of MHBC interventions will be conducted, one targeting health-related behaviours of patients with chronic conditions and another one targeting clinical behaviours of healthcare professionals.Materials and methods These systematic reviews will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A systematic search for MHBC interventions for patients will be performed in Web of Science, PubMed, CINAHL, EMBASE and Cochrane, and a systematic search for healthcare professionals will be conducted in the same databases. Studies from previous reviews will also be consulted. We will include randomised trials, in which interventions aim to change more than one behaviour (health-related for patients, clinical for HCPs). Components of the interventions will be extracted by using existing standardised classifications, such as ontologies (e.g. mode of delivery) and taxonomies (e.g. behaviour change techniques taxonomy v1), and the Cochrane Collaboration revised tool of Risk of Bias will be applied to perform risk of bias assessment. The components of included interventions will be synthesised and links between them will be mapped to identify trends and gaps. If sufficient comparable studies are included, a meta-analysis will be performed in both reviews. Systematic reviews registrationsCRD42022327085 and CRD42022327108
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