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Exploratory study of the dose-related safety, tolerability, and efficacy of dimethyltryptamine (DMT) in healthy volunteers and major depressive disorder

14 references·13 citing·33 second hopsampled

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References

2016Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial2,316 cited
2016Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study1,636 cited
2020Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder1,395 cited
2010Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer1,273 cited
2014Pilot study of the 5-HT 2A R agonist psilocybin in the treatment of tobacco addiction984 cited
2018Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial906 cited
2015Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report485 cited
1994Dose-Response Study of N,N-Dimethyltryptamine in Humans454 cited
2016Psychedelics as Medicines: An Emerging New Paradigm372 cited
2019Neural correlates of the DMT experience assessed with multivariate EEG314 cited
2008The GRID-HAMD: standardization of the Hamilton Depression Rating Scale295 cited
1995Human psychopharmacology of N,N-dimethyltryptamine260 cited
1956Dimethyltryptamin: Its metabolism in man; the relation of its psychotic effect to the serotonin metabolism203 cited

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2005

Psychological Effects of (S)-Ketamine and N,N-Dimethyltryptamine (DMT): A Double-Blind, Cross-Over Study in Healthy Volunteers

198 cited

Cited by

2024Adverse Events in Studies of Classic Psychedelics156 cited
2024Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis145 cited
2023Beyond the 5-HT2AReceptor: Classic and Nonclassic Targets in Psychedelic Drug Action93 cited
2023Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants89 cited
2023Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study88 cited
2023Serotonin 2A Receptor (5-HT 2A R) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants78 cited
2024Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial65 cited
2023Pharmacokinetics of N,N-dimethyltryptamine in Humans60 cited
2023Cardiovascular safety of psychedelic medicine: current status and future directions60 cited
2024Patient perspectives and experiences with psilocybin treatment for treatment-resistant depression: a qualitative study58 cited
2024Serotonergic Psychedelics: A Comparative Review of Efficacy, Safety, Pharmacokinetics, and Binding Profile57 cited
2022The economics of psychedelic-assisted therapies: A research agenda55 cited
2024Are “mystical experiences” essential for antidepressant actions of ketamine and the classic psychedelics?54 cited