Articlegold2022

Causal Relationship Between Sleep Traits and Risk of Systemic Lupus Erythematosus: A Two-Sample Mendelian Randomization Study

Ni Sang · Ruichen Gao · Meng-Yao Zhang · Zhenzhen Wu · Zhen-Gang Wu · Guo‐Cui Wu

53 citations0/0 files storedFrontiers in Immunology

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Abstract

A correlation between sleep and systemic lupus erythematosus (SLE) has been observed in a number of prior investigations. However, little is known regarding the potential causative relationship between them. In this study, we selected genetic instruments for sleep traits from pooled data from published genome-wide association studies (GWAS). Independent genetic variants associated with six sleep-related traits (chronotype, sleep duration, short sleep duration, long sleep duration, insomnia, and daytime sleepiness) were selected as instrumental variables. A two-sample Mendelian randomization (TSMR) study was first conducted to assess the causal relationship between sleep traits and SLE (7219 cases versus 15,991 controls). The reverse MR analysis was then used to infer the causal relationship between SLE and sleep traits. Inverse variance weighted (IVW), MR Egger, Weighted median, and Weighted mode were applied to perform the primary MR analysis. MR Egger regression and the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) test were used to detect horizontal pleiotropy, and Cochran’s Q was used to detect heterogeneity. In studies of the effect of sleep traits on SLE risk, the IVW method demonstrated no causal relationship between chronotype, sleep duration, short sleep duration, long sleep duration, insomnia, daytime sleepiness and SLE risk. The remaining three methods agreed with the results of IVW. In studies of the effect of SLE on the risk of sleep traits, neither IVW, MR Egger, Weighted median, nor Weighted mode methods provided evidence of a causal relationship between SLE and the risk of sleep traits. Overall, our study found no evidence of a bidirectional causal relationship between genetically predicted sleep traits and SLE.

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References

2019Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment 2019Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways 2019Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates 2019Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes 2019Sleep, circadian rhythm, and physical activity patterns in depressive and anxiety disorders: A 2‐week ambulatory assessment study 2005Determinants of sleep quality in women with systemic lupus erythematosus 2015Sleep Disorders and Increased Risk of Autoimmune Diseases in Individuals without Sleep Apnea 2014Sleep disorders and systemic lupus erythematosus

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