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This study aims to determine the influence of organizational culture and leadership style on job satisfaction and their impact on employee performance. This research was conducted at C-Care Cancer Research, Indonesia. The data were collected using questionnaires distributed to all employees in the Production, Research and Development, Finance and Administration, and Innovation and Product Development Divisions with 100 samples. The data analysis technique used was Structural Equation Modeling (SEM). The results showed that the culture of the organization positively influences job satisfaction. Leadership style does not significantly affect job satisfaction. While job satisfaction does not considerably affect the performance of employees, the employee's performance is negatively influenced by organizational culture. In addition, the employee's performance is negatively impacted by leadership style.
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