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Entrepreneurs in peripheral areas need to fully utilize a multidimensional regional environment in order to reduce regional innovation gaps. To gain a deeper theoretical and empirical understanding of the determinants of innovation processes in peripheral areas, this article sheds light not only on hard infrastructure and financial factors, but also on institutional, social, and relational factors. Studies of innovation in peripheral areas were conducted with the classic concept of regional innovation systems. Based on the results of a survey among 300 entrepreneurs in Polish peripheral regions, it was found that peripheral regions suffer from a deficit of human and social capital, particularly local leaders and mentoring and networking assistance. In addition, the analysis shows that peripheral regions do not have an effective innovation development strategy, lack institutional capital, and local authorities are not working to remove local barriers.
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