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Objective: to understand the meanings to hope attributed by Nursing professionals in the contextof the COVID-19 pandemic. Method: this is a qualitative, exploratory study with 719 Nursingprofessionals from five geographic regions of Brazil. Data were collected between April and June 2020,via a virtual questionnaire consisting of sociodemographic data and an open question. Iramuteqsoftware was used to process the data. Thematic content analysis and the hope model were adopted asan interpretive theoretical basis. Results: the meanings of hope are expressed in ambivalent feelings,which are overcome through spirituality and religiosity, which constitute strategies that promotehope. Interpersonal relationships and solidarity actions strengthen hope. Nursing professionalssupport their hopes in science, faith, and the potential of the health team. Conclusion: suchmeanings promote learning and reflections on the meaning of life, helping Nursing professionals toovercome the adverse daily life and take ownership of strategies that promote hope and resilience.
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