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This article examines sociospatial segregation and poverty in two mid-sized cities in Mexico. Data on population distribution, economic activities and poverty from 1970 to 2015 were analysed, on city and regional scales. The findings show persisting segregation on a regional scale, prioritising city centres while marginalising peripheries. It is highest among economically active, working-age, elderly and poorly educated populations. Growing centralisation was identified in tertiary economic activities and units. This unequal distribution has generated scarcities and exacerbated poverty. The findings from this theoretical–methodological approach show the need to recognise the relationships between the city and the surrounding region.
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