A digital platform for the design of patient-centric supply chains

Niki Triantafyllou · Andrea Bernardi · Matthew Lakelin · Nilay Shah · Maria M. Papathanasiou

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Supply Chain and Inventory Management Sustainable Supply Chain Management CAR-T cell therapy research

Abstract

Chimeric Antigen Receptor (CAR) T cell therapies have received increasing attention, showing promising results in the treatment of acute lymphoblastic leukaemia and aggressive B cell lymphoma. Unlike typical cancer treatments, autologous CAR T cell therapies are patient-specific; this makes them a unique therapeutic to manufacture and distribute. In this work, we focus on the development of a computer modelling tool to assist the design and assessment of supply chain structures that can reliably and cost-efficiently deliver autologous CAR T cell therapies. We focus on four demand scales (200, 500, 1000 and 2000 patients annually) and we assess the tool's capabilities with respect to the design of responsive supply chain candidate solutions while minimising cost.

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2009An optimization approach for managing fresh food quality throughout the supply chain 2001Design of Multi-echelon Supply Chain Networks under Demand Uncertainty 2015Supply chain design for efficient and effective blood supply in disasters 2019Survey on blood supply chain management: Models and methods 2014Multi-objective design of an organ transplant network under uncertainty 2019Incentivizing resilient supply chain design to prevent drug shortages: policy analysis using two- and multi-stage stochastic programs 2021An efficient optimization framework for tracking multiple quality attributes in supply chains of perishable products 2020Optimization of CAR T-cell therapies supply chains

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